Systemic and brain bioavailabilities of d-Phenylglycine-l-Dopa, a sustained dopamine-releasing prodrug
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چکیده
منابع مشابه
l-Dopa and Brain Serotonin System Dysfunction
L-dopa is used to treat the motor symptoms associated with Parkinson's disease, a neurodegenerative movement disorder characterized by a loss of dopamine neurons. L-dopa is the precursor to dopamine and crosses the blood-brain barrier to increase dopamine neurotransmission. This review will focus on the findings that dopamine produced from L-dopa is mediated in part by serotonin neurons. Direct...
متن کاملOn dopamine neurons . Nerve fiber outgrowth and L - DOPA effects
Cover illustration: Photomicrograph of dopamine nerve fibers (red) and astrocytes (green) in mice fetal ventral mesencephalic slice culture.
متن کاملChronic oral l-DOPA increases dopamine and decreases serotonin excretions.
Given the common pathways for uptake and synthesis for dopamine and serotonin, enhanced renal dopamine synthesis in response to increased substrate 3,4-dihydroxyphenylalanine (l-DOPA) is postulated to decrease renal serotonin synthesis. The present study compared the effects of chronic oral administration ofl-DOPA on dopamine and serotonin excretion in vivo, with the effects of enhanced dopamin...
متن کاملThe Design and Evaluation of an l-Dopa-Lazabemide Prodrug for the Treatment of Parkinson's Disease.
l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson's disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and less than 1% of the oral dose is estimated to reach the brain unchanged. l-Dopa's physicochemical properties are responsible for its poor bioavailability, short half-life and t...
متن کاملLiriodenine inhibits dopamine biosynthesis and L-DOPA-induced dopamine content in PC12 cells.
The inhibitory effects of liriodenine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and L-DOPA-induced dopamine content increases in PC12 cells were investigated. Treatment of PC12 cells with 5-10 microM liriodenine significantly decreased the intracellular dopamine content in a concentration-dependent manner (IC50 value, 8.4 microM). Liriodenine was not cytotoxic toward PC12 ce...
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ژورنال
عنوان ژورنال: Journal of Food and Drug Analysis
سال: 2013
ISSN: 1021-9498
DOI: 10.1016/j.jfda.2013.05.001